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Publications

  • Panetli JT, Forkus B, Forbes NS. Genetically modified bacteria to detect microscopic solid tumors: triggered release of a recombinant biomarker. Accepted for publication in Integrative Biology
  • Swofford CA, Van Dessel N, Forbes NS. Quorum-sensing Salmonella selectively trigger protein expression within tumors. Accepted for publication in PNAS.
  • Zhang M, Forbes NS. 2014. Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating. J Control Release. 199:180-189.
    • Cover article in the February 10th issue
  • Van Dessel N, Swofford CA, Forbes NS. Potent and tumor specific: Arming bacteria with therapeutic proteins. Accepted for publication in Therapeutic Delivery
  • St. Jean AT, Swofford CA, Brentzel ZJ†, Jan Panteli, Forbes NS. 2014. Bacterial delivery of Staphylococcus aureus alpha-hemolysin causes regression and necrosis in murine tumors. Mol Ther. 22:1266-74. Website
  • Kasinskas RW, Venkatasubramanian R, and Forbes NS. 2014. Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol. 6:399-410. PDF Website
  • Swofford CA, St. Jean AT, Panetli JT, Brentzel ZJ†, Forbes NS. 2014. Identification of Staphylococcus aureus α-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells. Biotechnol Bioeng. 111:1233-45. PDF Website
  • Zhang M, Swofford CA, Forbes NS. 2014. Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice. Int J Cancer. 135:647-57. PDF Website
  • Toley BJ, Tropeano-Lovatt Z, Harrington JL, Forbes NS. 2013. Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil. Integr. Biol. 5:1184-96 PDF Website
  • Dai Y, Toley BJ, Swofford CA, Forbes NS. 2013. Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue. Biotechnol Bioeng. 110:1769-81 PDF Website
  • Toley BJ, Forbes NS. 2012. Motility is critical for effective distribution and accumulation of bacteria in tumor tissue. Integr. Biol. 4:165-76 PDF Website
  • Toley BJ, Park J, Kim BJ, Venkatasubramanian R, Maharbiz MM, Forbes NS. 2012. Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro. Biotechnol Prog. 28:515-25. PDF Website
  • Toley BJ, Ganz DE, Walsh CL, Forbes NS. 2011. Microfluidic device for recreating a tumor microenvironment in vitro. J Vis Exp. DOI: 10.3791/2425. Website
  • Ganai S, Arenas RB, Sauer JP, Bentley B, Forbes NS. 2011. In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis. Cancer Gene Ther. 18:457-66 PDF Website
  • Forbes NS. 2010. Engineering the perfect (bacterial) cancer therapy. Nature Reviews Cancer. 10:785–794 PDF Website
  • Venkatasubramanian R, Arenas RB, Henson MA, Forbes NS. 2010. Mechanistic modeling of dynamic MRI data predicts that tumor heterogeneity decreases therapeutic response. Br J Cancer. 103:486-97 PDF Website
  • Kim BJ, Han G, Rotello VM, Forbes NS. 2010. Tuning payload delivery in tumor cylindroids using gold nanoparticles. Nat Nanotechnol. 5:465-72 PDF
  • Hunnewell M, Forbes NS. 2010. Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog. 26:789-96 PDF Website
  • Ganai S, Arenas RB, Forbes NS. 2009. Tumor-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice. Br J Cancer. 101:1683 PDF Website
  • Walsh CL, Babin BM, Kasinskas RW, Foster JA, McGarry MJ, Forbes NS. 2009. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab on a Chip. 9:545-554 PDF Website
  • Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. 2008. Efficient gene delivery vectors by tuning the surface charge density of amino-acid functionalized gold nanoparticles. ACS Nano. 2:2213-8 PDF Website
  • Forbes NS. 2008. A module to foster engineering creativity: an interpolative design problem and an extrapolative research project. Chemical Engineering Education 42:166172 PDF
  • St. Jean A, Zhang M Forbes NS. 2008. Bacterial therapies: completing the cancer treatment toolbox. Current Opinions in Biotechnology. 19:511-517 PDF Website
  • Kim BJ, Forbes NS. 2008.Single cell sorting in cylindroids demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumors. Biotechnology and Bioengineering. 101:797-810 PDF Website
  • Venkatasubramanian R, Henson MA, Forbes NS. 2008. Incorporating cell cycle progression and drug penetration into metabolic models of multicellular tumor spheroid growth. Journal of Theoretical Biology. 253:98–117 PDF Website
  • Kasinskas RW, Forbes NS. 2007. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 67:3201-9 PDF Website
  • Kim BJ, Forbes NS. 2007. Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. Biotechnol Bioeng. 96:1167-82 PDF Website
  • Ganai S, Arenas RB, Bentley B, Forbes NS. 2007. Targeting bacteriolytic therapy of solid tumors using Salmonella typhimurium. Annuls Surgical Oncology 14:71-71
  • Forbes NS. 2006. Profile of a bacterial tumor killer. Nat. Biotech. 24:1484-1485 PDF Website
  • Forbes NS*, Meadows AL, Clark DS, Blanch HW. 2006. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metabolic Engineering. 8:639-652 PDF Website
  • Venkatasubramanian R, Henson MA, Forbes NS. 2006. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 242:440-453 PDF Website
  • Kasinskas RW, Forbes NS. 2006. Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Biotechnology Bioengineering, 94:710-721 PDF Website
  • Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 45:3165-3169 PDF Website
  • Hong R, Han G, Fernandez JM, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 128:1078-9 PDF Website
  • Pinelis M, Kasinskas RW, Borno RT, Park JH, Chu E, Forbes NS, Maharbiz MM. 2006. Microfluidic devices for the assembly and culture of three-dimensional multi-cellular constructs with diffusion-limited microenvironments. Proceedings of the 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006). Japan
  • Han G, Hong R, Fernandez J, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated drug release using monolayer protected nanoparticle carriers. Abs Amer Chem Soc. 231:176
  • Han G, You CC, Kim BJ, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated DNA transcription and delivery using photolabile gold nanoparticles. Abs Amer Chem Soc. 231:266
  • Crichton MA, Forbes NS, Bhatia SR. 2005. USANS as a probe of large-scale structure in attractive colloidal glasses of block copolymer micelles.  MRS Symp. Proc. v. 840 - Neutron and X-Ray Scattering as Probes of Multiscale Phenomena. Q7.11.1-Q7.11.6
  • Forbes NS, Munn LL, Fukumura D, Jain RK. 2003. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 63:5188-5193
  • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. 2002. Acid production in variant, glycolysis-deficient and parental tumors in vivo: support for hypothesized tumor metabolism. Clin. Cancer Res. 8:1284-1291
  • Jain RK, Forbes NS. 2001. Can engineered bacteria help control cancer? PNAS 98:14748-14750
  • Forbes NS, Clark DS, Blanch HW. 2001. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. Biotech. Bioeng. 74:196-211
  • Forbes NS, Clark DS, Blanch HW. 2000. Analysis of metabolic fluxes in mammalian cells. Chap 4.4 in: Schügerl K, Bellgardt KH, editors. Bioreaction Engineering: Modeling and Control. Berlin: Springer Verlag