The Forbes Group at the University of Massachusetts

 

Publications

       
  1. Walsh CL, Babin BM, Kasinskas RW, Foster JA, McGarry MJ and Forbes NS. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Accepted for publication in Lab on a Chip
  2. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino-acid functionalized gold nanoparticles. Accepted for publication in ACS Nano
  3. Forbes NS. 2008. A module to foster engineering creativity: an interpolative design problem and an extrapolative research project. Chemical Engineering Education 42:166172
  4. St. Jean A, Zhang M Forbes NS. 2008. Bacterial therapies: completing the cancer treatment toolbox. Current Opinions in Biotechnology. 19:511-517
  5. Kim BJ, Forbes NS. 2008.Single cell sorting in cylindroids demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumors. Biotechnology and Bioengineering. 101:797-810
  6. Venkatasubramanian R, Henson MA, Forbes NS. 2008. Incorporating cell cycle progression and drug penetration into metabolic models of multicellular tumor spheroid growth. Journal of Theoretical Biology. 253:98–117
  7. Kasinskas RW, Forbes NS. 2007. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 67:3201-9
  8. Kim BJ, Forbes NS. 2007. Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. Biotechnol Bioeng. 96:1167-82
  9. Ganai S, Arenas RB, Bentley B, Forbes NS. 2007. Targeting bacteriolytic therapy of solid tumors using Salmonella typhimurium. Annuls Surgical Oncology 14:71-71
  10. Forbes NS. 2006. Profile of a bacterial tumor killer. Nat. Biotech. 24:1484-1485
  11. Forbes NS*, Meadows AL, Clark DS, Blanch HW. 2006. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metabolic Engineering. 8:639-652
  12. Venkatasubramanian R, Henson MA, Forbes NS. 2006. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 242:440-453
  13. Kasinskas RW, Forbes NS. 2006. Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Biotechnology Bioengineering, 94:710-721
  14. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 45:3165-3169
  15. Hong R, Han G, Fernandez JM, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 128:1078-9
  16. Pinelis M, Kasinskas RW, Borno RT, Park JH, Chu E, Forbes NS, Maharbiz MM. 2006. Microfluidic devices for the assembly and culture of three-dimensional multi-cellular constructs with diffusion-limited microenvironments. Proceedings of the 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006). Japan
  17. Han G, Hong R, Fernandez J, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated drug release using monolayer protected nanoparticle carriers. Abs Amer Chem Soc. 231:176
  18. Han G, You CC, Kim BJ, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated DNA transcription and delivery using photolabile gold nanoparticles. Abs Amer Chem Soc. 231:266
  19. Crichton MA, Forbes NS, Bhatia SR. 2005. USANS as a probe of large-scale structure in attractive colloidal glasses of block copolymer micelles.  MRS Symp. Proc. v. 840 - Neutron and X-Ray Scattering as Probes of Multiscale Phenomena. Q7.11.1-Q7.11.6
  20. Forbes NS, Munn LL, Fukumura D, Jain RK. 2003. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 63:5188-5193
  21. Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. 2002. Acid production in variant, glycolysis-deficient and parental tumors in vivo: support for hypothesized tumor metabolism. Clin. Cancer Res. 8:1284-1291
  22. Jain RK, Forbes NS. 2001. Can engineered bacteria help control cancer? PNAS 98:14748-14750
  23. Forbes NS, Clark DS, Blanch HW. 2001. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. Biotech. Bioeng. 74:196-211
  24. Forbes NS, Clark DS, Blanch HW. 2000. Analysis of metabolic fluxes in mammalian cells. Chap 4.4 in: Schügerl K, Bellgardt KH, editors. Bioreaction Engineering: Modeling and Control. Berlin: Springer Verlag

 

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