Research in the Forbes Lab is at the interface of engineering and medicine. We use fundamental principles to understand and control the mechanisms of human disease. The central theme of all projects is molecular transport in biological systems. The research is composed of experimental and computational techniques at the intersection of biomedical engineering, tumor biology, microbiology, and synthetic biology. Projects are focused on developing treatments for cancer, but this technology can be applied to many diseases and biomedical problems. Several specific research areas are:
- Engineer bacterial therapies that target tumors, penetrate tissue and deliver specifically designed anticancer molecules. We call this approach intratumoral therapeutic delivery. The ultimate goal is to create treatment modalities to treat patients with drug-resistant tumors and metastatic disease.
- Design of genetic circuits to control the motility and protein expression of bacterial vectors.
- Develop in vitro devices to quantify the transport of drugs and bacterial vectors in tumor tissue.
- Build computational tumor models to predict optimal drug designs and treatment strategies.
Congratulations to Miaomin Zhang on the acceptance of his paper entitled "Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating" into Journal of Controlled Delivery.
- Congratulations to Nele Van Dessel and Charles Swofford on the acceptance of their paper entitled "Potent and tumor specific: Arming bacteria with therapeutic proteins" into the journal Therapeutic Delivery.