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  • TITLE: A Quantitative Model of the Human Thyroid: Development and Observations
  • AUTHOR: M. Degon , Y. Chait , C.V. Hollot , S. Chipkin and T. Zoeller
  • ABSTRACT: A qualitative dynamical model of the human thyroid is derived using known intrathyriodal processes and pathways. It includes iodide transports from plasma into the cell and from the cell to the colloid, thyroid stimulating hormone signaling pathways, organification, endocytosis, proteolysis and hormone synthesis. The model structure is related quantitatively using nominal values of internal chemical concentrations, often utilizing Michaelis-Menton kinetics. Simulations at different conditions demonstrate the ability of our model to predict several types of known thyroid behavior.
  • STATUS: Presented at the ACC, June 8-10, 2005, Portland, Oregon, USA.
  • DATE OF ENTRY: January 3, 2005
  • full paper: (.pdf, 238 kb)

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Copyright & COPY; 2001 University of Massachusetts, Amherst. Produced and maintained by the University of Massachusetts, Mechanical Engineering department. Comments to: chait@ecs.umass.edu. This is an official page of the Mechanical & Industrial Engineering Department. Updated: Spring, 2001.