Engineering Tumor-Targeted Therapies

Forbes Research Group

at the University of Massachusetts Amherst

Neil St. John Forbes

 

 

Postdoctoral Fellowship, Radiation Oncology

Harvard Medical School / Massachusetts General Hospital

Advised by Rakesh K. Jain

 

Ph.D., Chemical Engineering

University of California at Berkeley

Advised by Harvey W. Blanch and Douglas S. Clark

 

B.S. Chemical Engineering

Case Western Reserve University

 

Publications

Forbes NS, Munn LL, Fukumura D, Jain RK. 2003. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 63:5188-5193.

Forbes NS, Clark DS, Blanch HW. 2003. Quantifying cancer metabolism: a novel tool for drug target discovery, consequences of malate-aspartate shuttle and intra-mitochondrial inactivity. In Progress.

Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. 2002. Acid production in variant, glycolysis-deficient and parental tumors in vivo: support for hypothesized tumor metabolism. Clin. Cancer Res. 8:1284-1291

Jain RK, Forbes NS. 2001. Can engineered bacteria help control cancer? PNAS 98:14748-14750

Forbes NS, Clark DS, Blanch HW. 2001. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. Biotech. Bioeng. 74:196-211

Forbes NS, Clark DS, Blanch HW. 2000. Analysis of metabolic fluxes in mammalian cells. Chap 4.4 in: Schügerl K, Bellgardt KH, editors. Bioreaction Engineering: Modeling and Control. Berlin: Springer Verlag

 

 

Invited Presentations

Forbes, NS. Engineering Tumor Therapies. Washington University, Department of Chemical Engineering Seminar. October 6, 2003

 

 

Presentations and Abstracts

Forbes NS, Munn L, Fukumura D, Jain RK. Sparse initial entrapment of systemically injected salmonella typhimurium leads to heterogeneous accumulation within tumors. Biochemical Engineering XIII: Biochemical Engineering in the Era of Genomics, Systems Biology, Genetic Medicine & Nanotechnologies. Boulder, CO. July 19-23, 2003

Forbes NS, Jain RK. Targeting Bacteria to Therapeutically Inaccessible Regions of Solid Tumors. American Association of Cancer Research. San Francisco, CA April 6-10, 2002

Cochran D, Forbes NS, Munn LL, Fukumura D, Jain RK. The role of HIF-1a in the response of embryonic stem cells to hypoxic microenvironments. Whitaker Foundation Biomedical Engineering Research Conference. La Jolla, CA. August 9-12, 2001

Wicklund KA, Forbes NS, Blanch HW, Clark DS. Response of Breast Cancer Cells to Estradiol and Tamoxifen: Quantitative NMR and Microcarrier Culture Studies. Department of Defense Breast Cancer Research Program Meeting. Atlanta, GA. June 10, 2000

Forbes NS, Clark DS, Blanch HW. The Metabolic Response of Breast Cancer Cells to Estradiol. AIChE Annual Meeting. Dallas, TX. November 1, 1999

Forbes NS, Clark DS, Blanch HW. Metabolic Flux Analysis to Characterize the Response of Human Breast Cancer Cells to Hormones.  Metabolic Engineering II. Elmau, Germany. October 25, 1998

 

 

Professional Societies

American Institute of Chemical Engineers

American Association of Cancer Researcher

International Society of Pharmaceutical Engineers

 

 

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