ChE 697A Molecular and Systems Biotechnology

Department of Chemical Engineering

Spring, 2005

Schedule | Reading List
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Instructors Professor Lianhong Sun 221 Goessmann Lab
5-6143 lsun@ecs.umass.edu

Professor Michael A. Henson 
259A Goessmann Lab 5-3481 henson@ecs.umass.edu
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Time: TTh 2:30-3:45pm

Lectures: Lederle 201

Office hours: Appointment by email

TA: None

Textbooks and handouts: No textbook is required. Class notes and reading assignments will be posted on the course web site before each class.

Grading: 10% paper presentation, 30% project presentations and 60% project report.

Email: All students are required to send Lianhong Sun an email message by 1/31/05. Include your preferred email address.  We will use email to announce schedule changes, update of the web site, etc.

Attendance: All students are expected to attend each class on time.

Course objectives:
  1. Introduction to the principles of molecular and systems biotechnology.
  2. Highlight current progress and future directions in molecular and systems biotechnology.

Course outcomes:
  1. Become familiar with the concepts of applied biocatalysis and its current status in the chemical and pharmaceutical industries.
  2. Gain a deep insight into protein engineering principles. Understand the strengths and constraints of three protein design methods: De novo design, rational design and directed evolution.  Know how to change properties of enzymes using related technologies, such as display technologies, genetic screen and selection, incorporation of unnatural amino acids.
  3. Understand how to use chemical biology methods to illuminate protein-protein interaction, synthesize small molecules with desired properties, and label biological systems.
  4. Be able to analyze genetic circuits and design simple artificial genetic systems.
  5. Develop an understanding of the theoretical underpinnings and the application of metabolic flux and control analysis.
  6. Become familiar with nonlinear modeling and analysis techniques for genetic regulatory, signal transduction and metabolic networks.
  7. Develop a sufficient command of the literature on molecular and systems biotechnology to pursue further studies.
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News:
May 11, 2005: The lecture note and reading assignments for the lecture 26 were posted.
May 9, 2005: The lecture note and reading assignments for the lecture 25 were posted.
May 4, 2005: The lecture note and reading assignments for the lecture 24 were posted.
May 2, 2005: The lecture note and reading assignments for the lecture 23 were posted.
April 25, 2005: The lecture note and reading assignments for the lecture 22 were posted.
April 22, 2005: The lecture note and reading assignments for the lecture 21 were posted.
April 18, 2005: The lecture note and reading assignments for the lecture 20 were posted.
April 13, 2005: The lecture note and reading assignments for the lecture 19 were posted.
April 11, 2005: The lecture note and reading assignments for the lecture 18 were posted.
April 4, 2005: The lecture note and reading assignments for the lecture 17 were posted.
March 30, 2005: The lecture note and reading assignments for the lecture 16 were posted.
March 28, 2005: The lecutre note and reading assignments for the lecture 15 were posted.
March 23, 2005:  The lecture note and reading assignments for the lecture 14 were posted.
March 20, 2005: The lecture note and reading assignments for the lecture 13 were posted.
March 18, 2005: The lecture note and reading assignments for the lecture 12 were posted.
March 07, 2005: The lecture notes and reading assignments for the lecture 10 & 11 were posted.
February 23, 2005: Project proposal writing guidline and template were posted.

February 21, 2005: The lecture notes and reading assignments for the Lectures 8&9 were posted.

February 16, 2005: The lecture note and reading assignments for the Lecture 7 were posted.

February 14, 2005: There was a slight change of schedule. Please read the new schedule.

February 14, 2005: The lecture note and reading assignments for the Lecture 6 were posted.

February 9, 2005: The lecture note and reading assignments for the Lecture 5 were posted.

February 7, 2005: The lecture note and reading assignments for the Lecture 4 were posted.

February 3, 2005: Two reference books (linked to Amazon.com) were added.

February 2, 2005: The lecture note and reading assingments for the Lecture 3 were posted.

January 27, 2005: The lecture note and reading assignments for the Lecture 2 were posted.

January 26, 2005: Reading list, the first lecture note, and readling assignments were posted.

January 17,2005: This web site was created.
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Class notes:

Lecture_26 (MAH)
Lecture_25 (MAH)
Lecture_24 (MAH)
Lecture_23 (MAH)
Lecture_22 (MAH)
Lecture_21 (MAH)
Lecture_20 (LS)
Lecture_19 (LS)
Lecture_18 (MAH)
Lecture_17 (MAH)
Lecture_16 (MAH)
Lecture_15 (MAH)
Lecture_14 (LS)
Lecture_13 (LS)
Lecture_12 (LS)
Lecture_11 (LS)
Lecture_10 (LS)

Lecture_9 (LS)

Lecure_8 (LS)

Lecture 7 (LS)

Lecture_6 (LS)

Lecture 5 (LS)

Lecture 4 (LS)

Lecture 3 (LS)

Lecture 2 (MAH)

Lecture 1 (LS)

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Reading Assignments:

Lecture_26 (MAH): 1, 2, 3, 4
Lecture_25 (MAH): 1, 2, 3, 4, 5
Lecture_24 (MAH): 1, 2, 3, 4, 5
Lecture_23 (MAH): 1, 2, 3
Lecture_22 (MAH): 1, 2, 3
Lecture_21 (MAH): 1, 2, 3, 4, 5
Lecture_20 (LS): 1, 2, 3, 4
Lecture_19 (LS): 1, 2, 3, 4
Lecture_18 (MAH): 1, 2
Lecture_17 (MAH): 1, 2, 3, 4, 5
Lecture_16 (MAH): 1, 2, 3, 4
Lecture_15 (MAH): 1
Lecture_14 (LS): 1, 2, 3
Lecture_13 (LS): 1, 2, 3, 4, 5, 6
Lecture_12 (LS): 1, 2, 3
Lecture_11 (LS): 1, 2, 3, 4, 5, 6,7,8
Lecture_10 (LS): 1, 2

Lecture 9 (LS): 1

Lecture 8 (LS): 1, 2, 3, 4, 5, 6

Lecture 7 (LS):  1234567

Lecture 6 (LS):  1234

Lecture 5 (LS): 1, 2, 3, 4

Lecture 4 (LS): 1, 2, 3, 4

Lecture 3 (LS): 1, 2, 3

Lecture 2 (MAH): 1, 2, 3

Lecture 1(LS): 1, 2, 3
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Reference Books


Instant Notes Series (Molecular biology, Biochemistry, and Microbiology)

Industrial Biotransformations by Andreas Liese, Larsten Seelbach, Christian Wandrey

Copyright
The copyright of the pictures and articles used in the course belongs to the original authors and publishers. Use of these materials is limited to the purpose of this course only. Distribution of class materials without written permission from the original owners is strictly prohibited.
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This site is best viewed by Netscape 7.2.
Please email  Professor Lianhong Sun for any problems and comments .